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However, the difference being, prednisone is in the inactive form which is converted into prednisolone in the liver, prednisone after which it becomes active . Hence, prednisolone is commonly prescribed as prednisone compared to prednisone . Prednisolone is available in the form of tablets, prednisone soluble tablets, liquid, eye and ear drops . Prednisolone and prednisone are roughly prednisone equivalent steroids, which are prescribed for similar treatments . As prednisolone is primarily a steroid, it are prednisolone and prednisone the same difference between prednisone and prednisolone prednisolone does affect our health in a positive as well as negative manner . In some cases, the liver might not be able to adequately convert prednisone into prednisone prednisolone . However, in case of liver failure difference between prednisone and prednisolone prednisolone to prednisone prednisolone versus prednisone cannot be used . It is also commonly used as a veterinary medicine prednisone too .

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