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Of the 1135 patients exposed to TOPAMAX� in the adult placebo-controlled studies, 25% topamax discontinued due to adverse reactions, compared to 10% of the 445 placebo patients . The adverse reactions associated with discontinuing therapy in the TOPAMAX� -treated patients included paresthesia (7%), fatigue (4%), topamax 200 what does topamax do to the brain topamax manufacturer does topamax cause anxiety how nausea (4%), difficulty with concentration/attention (3%), insomnia (3%), anorexia (2%), and dizziness (2%) .
c Adverse reactions reported by at least 1% of patients in the topamax TOPAMAX� 200-400 mg/day group and more common than in the placebo group are listed in this table .
The following additional adverse reactions that were not described in Table 10 were reported by greater than 1% of the 1367 TOPAMAX�-treated patients topamax in the controlled clinical trials: .

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