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Heartburn, the most common symptom of acid reflux, indigestion, and gastroesophageal reflux disease (GERD), also may occur with other diseases such as peptic ulcer disease. Heartburn is described as a substernal burning sensation that radiates upward toward the neck or throat.1 For many individuals, heartburn is mild, infrequent, and predictable. For others, heartburn is frequent (occurs 2 or more days a week), persistent, and more severe.
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